|Application ||WB, IHC-P, FC, IF, E|
|Calculated MW||69477 Da|
|Antigen Region||407-435 aa|
|Other Names||DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1|
|Target/Specificity||This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XRCC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.|
|Cellular Location||Nucleus. Note=Accumulates at sites of DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Lamerdin, J.E., et al. Genomics 25(2):547-554(1995)
Gyapay, G., et al. Nat. Genet. 7 (2 SPEC NO), 246-339 (1994) :
Thompson, L.H., et al. Mol. Cell. Biol. 10(12):6160-6171(1990)
Thompson, L.H., et al. Genomics 5(4):670-679(1989)
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