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XRCC1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • IF - XRCC1 Antibody (Center) AP5545C
    Immunofluorescent analysis of A549 cells, using XRCC1 Antibody (Center) (Cat. #AP5545c). AP5545c was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor® 554 (red) conjugated Phalloidin (red).
  • WB - XRCC1 Antibody (Center) AP5545C
    XRCC1 Antibody (Center) (Cat. #AP5545c) western blot analysis in A375 cell line lysates (15ug/lane).This demonstrates the XRCC1 antibody detected the XRCC1 protein (arrow).
  • IHC-P - XRCC1 Antibody (Center) AP5545C
    XRCC1 Antibody (Center) (Cat. #AP5545c) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the XRCC1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - XRCC1 Antibody (Center) AP5545C
    XRCC1 Antibody (Center) (Cat. #AP5545c) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18887
Other Accession NP_006288.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 69477 Da
Antigen Region 407-435 aa
Additional Information
Gene ID 7515
Other Names DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1
Target/Specificity This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.
Dilution IF~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXRCC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XRCC1
Function Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Cellular Location Nucleus. Note=Accumulates at sites of DNA damage
Research Areas
Citations (0)

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The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.


Lamerdin, J.E., et al. Genomics 25(2):547-554(1995)
Gyapay, G., et al. Nat. Genet. 7 (2 SPEC NO), 246-339 (1994) :
Thompson, L.H., et al. Mol. Cell. Biol. 10(12):6160-6171(1990)
Thompson, L.H., et al. Genomics 5(4):670-679(1989)

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Cat# AP5545C
(40 western blots)
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