|Application ||WB, IHC-P, E|
|Antigen Region||84-110 aa|
|Other Names||ATPase SWSAP1, SWIM-type zinc finger 7-associated protein 1, SWS1-associated protein 1, ZSWIM7-associated protein 1, ZSWIM7AP1, SWSAP1, C19orf39|
|Target/Specificity||This C19orf39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-110 amino acids from the Central region of human C19orf39.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C19orf39 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATPase which is preferentially stimulated by single- stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.|
|Cellular Location||Nucleus. EMBL; AK092438; BAC03891.1; -; mRNA EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC068071; AAH68071.1; -; mRNA EMBL; BC119677; AAI19678.1; -; mRNA CCDS; CCDS12259.1; - RefSeq; NP_787067.2; NM_175871.3 UniGene; Hs.631619; - ProteinModelPortal; Q6NVH7; - BioGrid; 125954; 10 IntAct; Q6NVH7; 6 STRING; 9606.ENSP00000310008; - iPTMnet; Q6NVH7; - PhosphoSitePlus; Q6NVH7; - BioMuta; SWSAP1; - DMDM; 74736850; - EPD; Q6NVH7; - MaxQB; Q6NVH7; - PaxDb; Q6NVH7; - PeptideAtlas; Q6NVH7; - PRIDE; Q6NVH7; - Ensembl; ENST00000312423; ENSP00000310008; ENSG00000173928 GeneID; 126074; - KEGG; hsa:126074; - UCSC; uc002mrg.2; human CTD; 126074; - GeneCards; SWSAP1; - HGNC; HGNC:26638; SWSAP1 HPA; HPA052712; - MIM; 614536; gene neXtProt; NX_Q6NVH7; - OpenTargets; ENSG00000173928; - PharmGKB; PA144596472; - eggNOG; ENOG410IGP0; Eukaryota eggNOG; ENOG41128AG; LUCA GeneTree; ENSGT00390000007170; - HOGENOM; HOG000001573; - HOVERGEN; HBG094964; - InParanoid; Q6NVH7; - OMA; PMRLQKI; - OrthoDB; EOG091G0F7H; - PhylomeDB; Q6NVH7; - TreeFam; TF337313; - GenomeRNAi; 126074; - PRO; PR:Q6NVH7; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000173928; - CleanEx; HS_C19orf39; - Genevisible; Q6NVH7; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0097196; C:Shu complex; IDA:UniProtKB GO; GO:0016887; F:ATPase activity; IDA:UniProtKB GO; GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB GO; GO:0050821; P:protein stabilization; IMP:UniProtKB Gene3D; 188.8.131.520; -; 1 InterPro; IPR027417; P-loop_NTPase InterPro; IPR033586; SWSAP1 PANTHER; PTHR28653; PTHR28653; 1 SUPFAM; SSF52540; SSF52540; 1 1: Evidence at protein level; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus; Polymorphism; Reference proteome CHAIN 1 229 ATPase SWSAP1 /FTId=PRO_0000294240 VARIANT 171 171 D -> G (in dbSNP:rs317926) /FTId=VAR_033151 MUTAGEN 18 18 K->A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. MUTAGEN 96 96 D->A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. CONFLICT 113 113 Y -> C (in Ref. 1; BAC03891) SEQUENCE 229 AA; 24311 MW; AB940178B7A4A6C6 CRC64; MPAAGPPLLL LGTPGSGKTA LLFAAALEAA GEGQGPVLFL TRRPLQSMPR GTGTTLDPMR LQKIRFQYPP STRELFRLLC SAHEAPGPAP SLLLLDGLEE YLAEDPEPQE AAYLIALLLD TAAHFSHRLG PGRDCGLMVA LQTQEEAGSG DVLHLALLQR YFPAQCWLQP DAPGPGEHGL RACLEPGGLG PRTEWWVTFR SDGEMMIAPW PTQAGDPSSG KGSSSGGQP|
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