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SRD5A2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP5552c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5552c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SRD5A2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P31213 |
| Other Accession | NP_000339.2 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 28393 Da |
SRD5A2 Antibody (Center) - Additional info | |
| Gene ID 6716 | |
| Other Names SRD5A2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; Type II 5-alpha reductase | |
| Target/Specificity This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from the Central region of human SRD5A2. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SRD5A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SRD5A2 Antibody (Center) - Protein Information | |
| Name SRD5A2 | |
| Function Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | |
| Cellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential) | |
| Tissue Location Expressed in high levels in the prostate and many other androgen-sensitive tissues | |
SRD5A2 Antibody (Center) - Related products
AP5552c: SRD5A2 Antibody (Center)
SRD5A2 Antibody (Center) - Application data
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SRD5A2 Antibody (Center) (Cat. #AP5552c) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow).
SRD5A2 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
REFERENCES
Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992) Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992) Labrie, F., et al. Endocrinology 131(3):1571-1573(1992) Andersson, S., et al. Nature 354(6349):159-161(1991)
