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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SRD5A2 Antibody (Center)   

SRD5A2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SRD5A2 Antibody (Center) AP5552c
    SRD5A2 Antibody (Center) (Cat. #AP5552c) western blot analysis in mouse kidney tissue lysates (15ug/lane).This demonstrates the SRD5A2 antibody detected SRD5A2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31213
Other Accession NP_000339.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28393 Da
Antigen Region 153-182 aa
Additional Information
Gene ID 6716
Other Names 3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase, SRD5A2
Target/Specificity This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the Central region of human SRD5A2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSRD5A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRD5A2
Function Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Cellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Expressed in high levels in the prostate and many other androgen-sensitive tissues
Research Areas
Citations (0)

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This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).


Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992)
Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992)
Labrie, F., et al. Endocrinology 131(3):1571-1573(1992)
Andersson, S., et al. Nature 354(6349):159-161(1991)

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$ 295.00
$ 99.00
Cat# AP5552c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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