|Application ||WB, IHC-P, IF, E|
|Calculated MW||17325 Da|
|Antigen Region||102-129 aa|
|Other Names||Vasopressin-neurophysin 2-copeptin, AVP-NPII, Arg-vasopressin, Arginine-vasopressin, Neurophysin 2, Neurophysin-II, Copeptin, AVP, ARVP, VP|
|Target/Specificity||This AVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human AVP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AVP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neurophysin 2 specifically binds vasopressin.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
Abu Libdeh, A., et al. Eur. J. Endocrinol. 162(2):221-226(2010)
Cirillo, M. Kidney Int. 77(1):5-6(2010)
Meijer, E., et al. Kidney Int. 77(1):29-36(2010)
Birk, J., et al. J. Cell. Sci. 122 (PT 21), 3994-4002 (2009)
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