|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9QY33, Q3SZR9, NP_005715.1|
|Calculated MW||28018 Da|
|Antigen Region||90-117 aa|
|Other Names||Tetraspanin-3, Tspan-3, Tetraspanin TM4-A, Transmembrane 4 superfamily member 8, TSPAN3, TM4SF8|
|Target/Specificity||This TSPAN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human TSPAN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSPAN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene.
Berditchevski, F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001) :
Todd, S.C., et al. Biochim. Biophys. Acta 1399(1):101-104(1998)
Wu, Y.J., et al. J. Biol. Chem. 266(26):17566-17572(1991)
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