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PREPL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q4J6C6 |
| Other Accession | Q5HZA6, Q8C167, A5LFV8, NP_006027.2 |
| Reactivity | Human, Hamster, Mouse |
| Predicted | Monkey, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83927 Da |
| Antigen Region | 624-652 aa |
| Gene ID | 9581 |
|---|---|
| Other Names | Prolyl endopeptidase-like, 3421-, Prolylendopeptidase-like, PREPL, KIAA0436 |
| Target/Specificity | This PREPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-652 amino acids from the C-terminal region of human PREPL. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PREPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PREPL |
|---|---|
| Synonyms | KIAA0436 |
| Function | Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330). |
| Cellular Location | Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity) Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity) Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167} |
| Tissue Location | Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome.
References
Parvari, R., et al. Genomics 86(2):195-211(2005)
Kim, D.K., et al. Biochim. Biophys. Acta 1565(1):112-121(2002)
Parvari, R., et al. Am. J. Hum. Genet. 69(4):869-875(2001)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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