|Application ||WB, IHC-P, FC, E|
|Calculated MW||56056 Da|
|Antigen Region||226-253 aa|
|Other Names||Metalloreductase STEAP2, 1161-, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, STEAP2, PCANAP1, STAMP1|
|Target/Specificity||This STEAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-253 amino acids from the Central region of human STEAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STEA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Vaghjiani, R.J., et al. Tissue Eng Part A 15(8):2073-2083(2009)
Denoeud, F., et al. Genome Res. 17(6):746-759(2007)
Ohgami, R.S., et al. Blood 108(4):1388-1394(2006)
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