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STEA2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - STEA2 Antibody (Center) AP5583c
    Western blot analysis of lysates from 293, HepG2 cell line, mouse spleen tissue lysate (from left to right), using STEAP2 Antibody (Center)(Cat. #AP5583c). AP5583c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • WB - STEA2 Antibody (Center) AP5583c
    Western blot analysis of extracts from 293 (lanes 1 and 2),HepG2 (lanes 3 and 4)cell line and mouse spleen (lanes 5 and 6)tissue lysate: 1, 3, 5. using STEAP2 Antibody (Center)( AP5583c), (1:500). 2, 4, 6. using STEAP2 Antibody (Center), preincubated with the control peptide antigen.
  • IHC-P - STEA2 Antibody (Center) AP5583c
    STEAP2 Antibody (Center) (Cat. #AP5583c) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STEAP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - STEA2 Antibody (Center) AP5583c
    STEAP2 Antibody (Center) (Cat. #AP5583c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NFT2
Other Accession NP_001035756.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56056 Da
Antigen Region 226-253 aa
Additional Information
Gene ID 261729
Other Names Metalloreductase STEAP2, 1161-, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, STEAP2, PCANAP1, STAMP1
Target/Specificity This STEAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-253 amino acids from the Central region of human STEAP2.
Dilution WB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTEA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PCANAP1, STAMP1
Function Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
Cellular Location Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
Research Areas
Citations (0)

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This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.


Vaghjiani, R.J., et al. Tissue Eng Part A 15(8):2073-2083(2009)
Denoeud, F., et al. Genome Res. 17(6):746-759(2007)
Ohgami, R.S., et al. Blood 108(4):1388-1394(2006)

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$ 295.00
$ 99.00
Cat# AP5583c
(40 western blots)
Availability: In Stock
Bulk Size
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