|Application ||WB, FC, E|
|Other Accession||Q64689, NP_056963.2|
|Calculated MW||43970 Da|
|Antigen Region||312-340 aa|
|Other Names||Sia-alpha-2, 3-Gal-beta-1, 4-GlcNAc-R:alpha 2, 8-sialyltransferase, 2499-, Alpha-2, 8-sialyltransferase 8C, Alpha-2, 8-sialyltransferase III, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 3, Sialyltransferase 8C, SIAT8-C, Sialyltransferase St8Sia III, ST8SiaIII, ST8SIA3, SIAT8C|
|Target/Specificity||This SIA8C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the C-terminal region of human SIA8C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIA8C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in fetal and adult brain and fetal liver.|
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Provided below are standard protocols that you may find useful for product applications.
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Kim, S.J., et al. Biochem. Biophys. Res. Commun. 344(4):1057-1064(2006)
Angata, K., et al. J. Biol. Chem. 275(24):18594-18601(2000)
Lee, Y.C., et al. Arch. Biochem. Biophys. 360(1):41-46(1998)
Zeng, G., et al. Gene 187(1):131-134(1997)
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