- CITATIONS: 4
|Application ||WB, IHC-P, FC, E|
|Calculated MW||19330 Da|
|Antigen Region||89-116 aa|
|Other Names||Regenerating islet-derived protein 3-gamma, REG-3-gamma, Pancreatitis-associated protein 1B, PAP-1B, Pancreatitis-associated protein IB, PAP IB, Regenerating islet-derived protein III-gamma, REG III, Reg III-gamma, Regenerating islet-derived protein 3-gamma 165 kDa form, Regenerating islet-derived protein 3-gamma 15 kDa form, REG3G, PAP1B|
|Target/Specificity||This REG3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-116 amino acids from the Central region of human REG3G.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||REG3G Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.|
|Cellular Location||Secreted. Cytoplasm.|
|Tissue Location||Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta|
Provided below are standard protocols that you may find useful for product applications.
REG3G might be a stress protein involved in the control of bacterial proliferation (By similarity).
Taylor-Fishwick, D.A., et al. J. Histochem. Cytochem. 56(2):183-191(2008)
Hamblet, N.S., et al. Pancreas 36(1):1-9(2008)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Laurine, E., et al. Biochim. Biophys. Acta 1727(3):177-187(2005)
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