DI3L1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q8TF46 |
Other Accession | A0JN80, NP_001137160.1 |
Reactivity | Human, Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 120787 Da |
Antigen Region | 195-224 aa |
Gene ID | 115752 |
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Other Names | DIS3-like exonuclease 1, 3113-, DIS3L, DIS3L1, KIAA1955 |
Target/Specificity | This DI3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the N-terminal region of human DI3L1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DI3L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DIS3L |
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Synonyms | DIS3L1, KIAA1955 |
Function | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389). |
Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
DIS3L is a probable exonuclease. It has four isoforms.
References
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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