|Application ||WB, IHC-P, E|
|Other Accession||A0JN80, NP_001137160.1|
|Calculated MW||120787 Da|
|Antigen Region||195-224 aa|
|Other Names||DIS3-like exonuclease 1, 3113-, DIS3L, DIS3L1, KIAA1955|
|Target/Specificity||This DI3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the N-terminal region of human DI3L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DI3L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.|
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Provided below are standard protocols that you may find useful for product applications.
DIS3L is a probable exonuclease. It has four isoforms.
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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