EID2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8N6I1 |
Other Accession | NP_694964.3 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25190 Da |
Antigen Region | 177-208 aa |
Gene ID | 163126 |
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Other Names | EP300-interacting inhibitor of differentiation 2, EID-2, CREBBP/EP300 inhibitor 2, EID-1-like inhibitor of differentiation 2, EID2 {ECO:0000312|EMBL:AAH301373} |
Target/Specificity | This EID2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the C-terminal region of human EID2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EID2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EID2 {ECO:0000312|EMBL:AAH30137.3} |
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Function | Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3- dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. |
Cellular Location | Nucleus. |
Tissue Location | Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
EID2 interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. It may act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
References
Lee, H.J., et al. J. Biol. Chem. 279(4):2666-2672(2004)
Ji, A., et al. Gene 318, 35-43 (2003) :
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