N4BP3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O15049 |
Other Accession | NP_055926.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 60470 Da |
Antigen Region | 50-79 aa |
Gene ID | 23138 |
---|---|
Other Names | NEDD4-binding protein 3, N4BP3, N4BP3, KIAA0341 |
Target/Specificity | This N4BP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human N4BP3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | N4BP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | N4BP3 |
---|---|
Synonyms | KIAA0341 |
Function | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). |
Cellular Location | Cytoplasmic vesicle. Cell projection, axon {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites {ECO:0000250|UniProtKB:Q3LUD3} |
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Provided below are standard protocols that you may find useful for product applications.
References
Murillas, R., et al. J. Biol. Chem. 277(4):2897-2907(2002)
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