|Application ||WB, FC, E|
|Other Accession||Q10836, Q8K093, NP_037513.1|
|Calculated MW||117000 Da|
|Antigen Region||951-980 aa|
|Other Names||Thyrotropin-releasing hormone-degrading ectoenzyme, TRH-DE, TRH-degrading ectoenzyme, Pyroglutamyl-peptidase II, PAP-II, TRH-specific aminopeptidase, Thyroliberinase, TRHDE|
|Target/Specificity||This TRHDE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 951-980 amino acids from the C-terminal region of human TRHDE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRHDE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specific inactivation of TRH after its release.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Predominantly expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the peptidase M1 family. TRHDE is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.
Cirulli, E.T., et al. Eur. J. Hum. Genet. (2010) In press :
Murabito, J.M., et al. BMC Med. Genet. 8 SUPPL 1, S6 (2007) :
Schomburg, L., et al. Eur. J. Biochem. 265(1):415-422(1999)
Bodeker, H., et al. Mol. Cell Biol. Res. Commun. 2(3):150-154(1999)
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