|Application ||WB, IHC-P, E|
|Calculated MW||136044 Da|
|Antigen Region||1186-1214 aa|
|Other Names||Sodium bicarbonate cotransporter 3, Electroneutral Na/HCO(3) cotransporter, Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b, Bicarbonate transporter, Solute carrier family 4 member 7, SLC4A7, BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4A6|
|Target/Specificity||This SLC4A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1186-1214 amino acids from the C-terminal region of human SLC4A7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC4A7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4|
|Function||Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, stereocilium. Note=Also described at the apical cell membrane Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity)|
|Tissue Location||Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SLC4A7 regulates intracellular pH and may also play a role in bicarbonate salvage in secretory epithelia. Additionally, SLC4A7 may also have associated sodium channel activity.
Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)
Ahmed, S., et al. Nat. Genet. 41(5):585-590(2009)
Ishiguro, H., et al. Addiction 102(8):1320-1325(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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