|Application ||WB, FC, E|
|Other Accession||Q9QXP4, NP_060083|
|Calculated MW||62747 Da|
|Antigen Region||368-398 aa|
|Other Names||Protein downstream neighbor of Son, B17, DONSON, C21orf60|
|Target/Specificity||This DONSON antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-398 amino acids from the Central region of human DONSON.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DONSON Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.|
|Cellular Location||Nucleus. Note=Localizes at DNA replication sites|
|Tissue Location||Expressed in the brain, with higher levels in prenatal compared to adult brain.|
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Provided below are standard protocols that you may find useful for product applications.
DONSON lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq].
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Gardiner, K., et al. Genomics 79(6):833-843(2002)
Wynn, S.L., et al. Genomics 68(1):57-62(2000)
Slavov, D., et al. Gene 247 (1-2), 215-232 (2000) :
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