|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||P13589, P41535, O70176, NP_001093203.1|
|Predicted||Mouse, Pig, Rat|
|Calculated MW||18835 Da|
|Antigen Region||148-176 aa|
|Other Names||Pituitary adenylate cyclase-activating polypeptide, PACAP, PACAP-related peptide, PRP-48, Pituitary adenylate cyclase-activating polypeptide 27, PACAP-27, PACAP27, Pituitary adenylate cyclase-activating polypeptide 38, PACAP-38, PACAP38, ADCYAP1|
|Target/Specificity||This ADCYAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human ADCYAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCYAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.|
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Provided below are standard protocols that you may find useful for product applications.
ADCYAP1 is adenylate cyclase activating polypeptide 1. Mediated by adenylate cyclase activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase activating polypeptide 1 is not only a hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This gene encodes three different mature peptides, including two isotypes, a shorter form and a longer form.
Hosoya, M., et al. Biochim. Biophys. Acta 1129(2):199-206(1992)
Ohkubo, S., et al. DNA Cell Biol. 11(1):21-30(1992)
Kimura, C., et al. Biochem. Biophys. Res. Commun. 166(1):81-89(1990)
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