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P2RX7 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - P2RX7 Antibody (C-term) AP5674b
    P2RX7 Antibody (C-term) (Cat. #AP5674b) western blot analysis in MDA-MB435 cell line and mouse kidney tissue lysates (15ug/lane).This demonstrates the P2RX7 antibody detected the P2RX7 protein (arrow).
  • IHC-P - P2RX7 Antibody (C-term) AP5674b
    P2RX7 Antibody (C-term) (Cat. #AP5674b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the P2RX7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99572
Other Accession NP_002553.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68585 Da
Antigen Region 563-592 aa
Additional Information
Gene ID 5027
Other Names P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7
Target/Specificity This P2RX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-592 amino acids from the C-terminal region of human P2RX7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsP2RX7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RX7
Function Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed with highest levels in brain and immune tissues.
Research Areas
Citations ( 0 )


P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.


Kim, M., et al. EMBO J. 20(22):6347-6358(2001)
Gartland, A., et al. J. Bone Miner. Res. 16(5):846-856(2001)
Gu, B.J., et al. J. Biol. Chem. 276(14):11135-11142(2001)
Buell, G.N., et al. Recept. Channels 5(6):347-354(1998)
Rassendren, F., et al. J. Biol. Chem. 272(9):5482-5486(1997)

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$ 295.00
$ 99.00
Cat# AP5674b
(40 western blots)
Availability: In Stock
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