CALCR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF, FC, E |
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Primary Accession | P30988 |
Other Accession | NP_001733.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55345 Da |
Antigen Region | 465-494 aa |
Gene ID | 799 |
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Other Names | Calcitonin receptor, CT-R, CALCR |
Target/Specificity | This CALCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids of human CALCR. |
Dilution | IF~~1:10~50 WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CALCR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CALCR (HGNC:1440) |
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Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CALCR is a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis.
References
Nussenzveig, D.R., et al. Endocrinology 136(5):2047-2051(1995) Nakamura, M., et al. Biochem. Biophys. Res. Commun. 209(2):744-751(1995) Egerton, M., et al. J. Mol. Endocrinol. 14(2):179-189(1995) Gorn, A.H., et al. J. Clin. Invest. 90(5):1726-1735(1992)
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