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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CFHR5 Antibody (Center)   

CFHR5 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CFHR5 Antibody (Center) AP5689C
    CFHR5 Antibody (Center) (Cat. #AP5689c) western blot analysis in CEM(lane 1),K562(lane 2) cell line lysates (15ug/lane).This demonstrates the CFHR5 antibody detected the CFHR5 protein (arrow).
  • IHC-P - CFHR5 Antibody (Center) AP5689C
    CFHR5 Antibody (Center) (Cat. #AP5689c) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CFHR5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CFHR5 Antibody (Center) AP5689C
    CFHR5 Antibody (Center) (Cat. #AP5689c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXR6
Other Accession NP_110414.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64419 Da
Antigen Region 203-231 aa
Additional Information
Gene ID 81494
Other Names Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5
Target/Specificity This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCFHR5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFHR5
Synonyms CFHL5, FHR5
Function Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq].


McRae, J.L., et al. Genetica 114(2):157-161(2002)
Murphy, B., et al. Am. J. Kidney Dis. 39(1):24-27(2002)
Narkio-Makela, M., et al. Clin. Immunol. 100(1):118-126(2001)
McRae, J.L., et al. J. Biol. Chem. 276(9):6747-6754(2001)

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Cat# AP5689C
(40 western blots)
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