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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   GP6 Antibody (C-term)   

GP6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GP6 Antibody (C-term) AP5691b
    GP6 Antibody (C-term) (Cat. #AP5691b) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the GP6 antibody detected the GP6 protein (arrow).
  • FC - GP6 Antibody (C-term) AP5691b
    GP6 Antibody (C-term) (Cat. #AP5691b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCN6
Other Accession NP_057447.4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36866 Da
Antigen Region 309-337 aa
Additional Information
Gene ID 51206
Other Names Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6
Target/Specificity This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGP6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GP6
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
Cellular Location Isoform 1: Cell membrane; Single-pass membrane protein
Tissue Location Megakaryocytes and platelets.
Research Areas
Citations (0)

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Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).


Polgar, J., et al. J. Biol. Chem. 272(21):13576-13583(1997)
Asselin, J., et al. Blood 89(4):1235-1242(1997)
Huang, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 88(17):7844-7848(1991)
Moroi, M., et al. J. Clin. Invest. 84(5):1440-1445(1989)

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Cat# AP5691b
(40 western blots)
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