|Application ||WB, FC, E|
|Calculated MW||36866 Da|
|Antigen Region||309-337 aa|
|Other Names||Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6|
|Target/Specificity||This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GP6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass membrane protein|
|Tissue Location||Megakaryocytes and platelets.|
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Provided below are standard protocols that you may find useful for product applications.
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).
Polgar, J., et al. J. Biol. Chem. 272(21):13576-13583(1997)
Asselin, J., et al. Blood 89(4):1235-1242(1997)
Huang, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 88(17):7844-7848(1991)
Moroi, M., et al. J. Clin. Invest. 84(5):1440-1445(1989)
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