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FBXO34 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NWN3 |
| Other Accession | Q80XI1, NP_060413.2 |
| Reactivity | Human, Hamster |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 78711 Da |
| Antigen Region | 600-629 aa |
| Gene ID | 55030 |
|---|---|
| Other Names | F-box only protein 34, FBXO34, FBX34 |
| Target/Specificity | This FBXO34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 600-629 amino acids from the C-terminal region of human FBXO34. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXO34 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO34 |
|---|---|
| Synonyms | FBX34 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
References
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
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