|Application ||WB, IHC-P, E|
|Calculated MW||25694 Da|
|Antigen Region||167-193 aa|
|Other Names||E3 ubiquitin-protein ligase RNF114, 632-, RING finger protein 114, Zinc finger protein 228, Zinc finger protein 313, RNF114, ZNF228, ZNF313|
|Target/Specificity||This ZNF313 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-193 amino acids from the C-terminal region of human ZNF313.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF313 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ZNF313 is a novel human zinc finger protein gene that contains both ring finger and C(2)H(2) domain. It may play a role in spermatogenesis.
Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)
Ma, Y.X., et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35(3):230-237(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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