ZNF313 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9Y508 |
Other Accession | NP_061153.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25694 Da |
Antigen Region | 167-193 aa |
Gene ID | 55905 |
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Other Names | E3 ubiquitin-protein ligase RNF114, 632-, RING finger protein 114, Zinc finger protein 228, Zinc finger protein 313, RNF114, ZNF228, ZNF313 |
Target/Specificity | This ZNF313 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-193 amino acids from the C-terminal region of human ZNF313. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZNF313 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNF114 |
---|---|
Synonyms | ZNF228, ZNF313 |
Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF313 is a novel human zinc finger protein gene that contains both ring finger and C(2)H(2) domain. It may play a role in spermatogenesis.
References
Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)
Ma, Y.X., et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35(3):230-237(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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