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ZNF313 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZNF313 Antibody (C-term) AP5694B
    ZNF313 Antibody (C-term) (Cat. #AP5694b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ZNF313 antibody detected the ZNF313 protein (arrow).
    detail
  • IHC-P - ZNF313 Antibody (C-term) AP5694B
    ZNF313 Antibody (C-term) (Cat. #AP5694b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZNF313 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y508
Other Accession NP_061153.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 25694 Da
Antigen Region 167-193 aa
Additional Information
Gene ID 55905
Other Names E3 ubiquitin-protein ligase RNF114, 632-, RING finger protein 114, Zinc finger protein 228, Zinc finger protein 313, RNF114, ZNF228, ZNF313
Target/Specificity This ZNF313 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-193 amino acids from the C-terminal region of human ZNF313.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZNF313 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF114
Synonyms ZNF228, ZNF313
Function E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis
Research Areas
Citations (0)
citation

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Background

ZNF313 is a novel human zinc finger protein gene that contains both ring finger and C(2)H(2) domain. It may play a role in spermatogenesis.

References

Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)
Ma, Y.X., et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35(3):230-237(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 365.00
$ 140.00
Cat# AP5694B
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