|Application ||WB, IHC-P, E|
|Calculated MW||25694 Da|
|Antigen Region||167-193 aa|
|Other Names||E3 ubiquitin-protein ligase RNF114, 632-, RING finger protein 114, Zinc finger protein 228, Zinc finger protein 313, RNF114, ZNF228, ZNF313|
|Target/Specificity||This ZNF313 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-193 amino acids from the C-terminal region of human ZNF313.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF313 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis|
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Provided below are standard protocols that you may find useful for product applications.
ZNF313 is a novel human zinc finger protein gene that contains both ring finger and C(2)H(2) domain. It may play a role in spermatogenesis.
Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)
Ma, Y.X., et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35(3):230-237(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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