|Application ||FC, WB, IHC-P, E|
|Other Accession||Q3SYR3, NP_006780.1|
|Calculated MW||25703 Da|
|Antigen Region||19-48 aa|
|Other Names||Probable C->U-editing enzyme APOBEC-2, 354-, APOBEC2|
|Target/Specificity||This APOBEC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human APOBEC2.|
|Precautions||APOBEC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|
|Tissue Location||Expressed exclusively in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
APOBEC2 belongs to the cytidine and deoxycytidylate deaminase family. It is probable C to U editing enzyme whose physiological substrate is not yet known. It does not display detectable apoB mRNA editing and has a low intrinsic cytidine deaminase activity.
Liao, W., et al. Biochem. Biophys. Res. Commun. 260(2):398-404(1999)
Oka, K., et al. J. Biol. Chem. 272(3):1456-1460(1997)
Lau, P.P., et al. Proc. Natl. Acad. Sci. U.S.A. 91(18):8522-8526(1994)
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