|Application ||FC, WB, E|
|Calculated MW||38119 Da|
|Antigen Region||316-343 aa|
|Other Names||Sodium/bile acid cotransporter, Cell growth-inhibiting gene 29 protein, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Sodium/taurocholate cotransporting polypeptide, Solute carrier family 10 member 1, SLC10A1, NTCP|
|Target/Specificity||This SLC10A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-343 amino acids from the C-terminal region of human SLC10A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC10A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).
Ho, R.H., et al. J. Biol. Chem. 279(8):7213-7222(2004)
Trauner, M., et al. Physiol. Rev. 83(2):633-671(2003)
Hallen, S., et al. Biochemistry 41(23):7253-7266(2002)
Shiao, T., et al. Genomics 69(2):203-213(2000)
Hagenbuch, B., et al. J. Clin. Invest. 93(3):1326-1331(1994)
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