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RSPO4 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP5711b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5711b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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- Backgrounds
RSPO4 Antibody (C-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | Q2I0M5 |
| Other Accession | NP_001025042.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 26171 Da |
RSPO4 Antibody (C-term) - Additional info | |
| Gene ID 343637 | |
| Other Names RSPO4; C20orf182; R-spondin-4; Roof plate-specific spondin-4 | |
| Target/Specificity This RSPO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human RSPO4. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RSPO4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RSPO4 Antibody (C-term) - Protein Information | |
| Name RSPO4 | |
| Synonyms C20orf182 | |
| Function Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity) | |
| Cellular Location Secreted (By similarity). | |
RSPO4 Antibody (C-term) - Related products
RSPO4 Antibody (C-term) - Application data
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RSPO4 Antibody (C-term) (Cat. #AP5711b) western blot analysis in Jurkat cell line lysates (15ug/lane).This demonstrates the RSPO4 antibody detected the RSPO4 protein (arrow).
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RSPO4 Antibody (C-term) (Cat. #AP5711b) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RSPO4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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RSPO4 Antibody (C-term) (Cat. #AP5711b) flow cytometric analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
RSPO4 Antibody (C-term) - Research Areas
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BACKGROUND
RSPO4 is a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.
REFERENCES
Bergmann, C., et al. Am. J. Hum. Genet. 79(6):1105-1109(2006) Blaydon, D.C., et al. Nat. Genet. 38(11):1245-1247(2006) Kim, K.A., et al. Cell Cycle 5(1):23-26(2006)
