|Application ||WB, IHC-P, FC, E|
|Other Accession||Q6NWW5, NP_919289.2|
|Calculated MW||151903 Da|
|Antigen Region||356-384 aa|
|Other Names||Kinesin-like protein KIF24, KIF24, C9orf48|
|Target/Specificity||This KIF24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-384 amino acids from the N-terminal region of human KIF24.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF24 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole|
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Provided below are standard protocols that you may find useful for product applications.
Tsuritani, K., et al. Genome Res. 17(7):1005-1014(2007)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Miki, H., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7004-7011(2001)
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