- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Other Accession||P35953, NP_003374.3|
|Calculated MW||96098 Da|
|Antigen Region||484-510 aa|
|Other Names||Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR|
|Target/Specificity||This VLDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-510 amino acids from the Central region of human VLDLR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VLDLR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein|
|Tissue Location||Abundant in heart and skeletal muscle; also ovary and kidney; not in liver|
Provided below are standard protocols that you may find useful for product applications.
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq].
Sakai, K., et al. Brain Res. 1276, 11-21 (2009)
Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)
Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)
Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.