- CITATIONS: 3
|Application ||WB, E|
|Calculated MW||100875 Da|
|Antigen Region||817-844 aa|
|Other Names||Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, NDST-2, N-heparan sulfate sulfotransferase 2, N-HSST 2, Heparan sulfate N-deacetylase 2, 3---, Heparan sulfate N-sulfotransferase 2, 282-, NDST2, HSST2|
|Target/Specificity||This NDST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-844 amino acids of human NDST2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDST2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
Provided below are standard protocols that you may find useful for product applications.
NDST2 is a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi.
Duncan, M.B., et al. Biochem. Biophys. Res. Commun. 339(4):1232-1237(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Carter, N.M., et al. J. Cell. Sci. 116 (PT 17), 3591-3600 (2003)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.