- CITATIONS: 3
|Application ||WB, E|
|Calculated MW||100875 Da|
|Antigen Region||817-844 aa|
|Other Names||Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, NDST-2, N-heparan sulfate sulfotransferase 2, N-HSST 2, Heparan sulfate N-deacetylase 2, 3---, Heparan sulfate N-sulfotransferase 2, 282-, NDST2, HSST2|
|Target/Specificity||This NDST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-844 amino acids of human NDST2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDST2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
Provided below are standard protocols that you may find useful for product applications.
NDST2 is a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi.
Duncan, M.B., et al. Biochem. Biophys. Res. Commun. 339(4):1232-1237(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Carter, N.M., et al. J. Cell. Sci. 116 (PT 17), 3591-3600 (2003)
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