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NDST2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P52849 |
| Other Accession | NP_003626.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 100875 Da |
| Antigen Region | 817-844 aa |
| Gene ID | 8509 |
|---|---|
| Other Names | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, NDST-2, N-heparan sulfate sulfotransferase 2, N-HSST 2, Heparan sulfate N-deacetylase 2, 3---, Heparan sulfate N-sulfotransferase 2, 282-, NDST2, HSST2 |
| Target/Specificity | This NDST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-844 amino acids of human NDST2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NDST2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NDST2 |
|---|---|
| Synonyms | HSST2 |
| Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Provided below are standard protocols that you may find useful for product applications.
Background
NDST2 is a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi.
References
Duncan, M.B., et al. Biochem. Biophys. Res. Commun. 339(4):1232-1237(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Carter, N.M., et al. J. Cell. Sci. 116 (PT 17), 3591-3600 (2003)
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