|Application ||WB, IHC-P, IF, E|
|Calculated MW||39397 Da|
|Antigen Region||74-101 aa|
|Other Names||Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2|
|Target/Specificity||This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-101 amino acids from the Central region of human PON2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PON2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed with highest expression in liver, lung, placenta, testis and heart|
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Provided below are standard protocols that you may find useful for product applications.
PON2 is a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.
Sanghera, D.K., et al. Am. J. Hum. Genet. 62(1):36-44(1998)
Hegele, R.A., et al. J. Clin. Endocrinol. Metab. 82(10):3373-3377(1997)
Primo-Parmo, S.L., et al. Genomics 33(3):498-507(1996)
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