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BIN2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BIN2 Antibody  (N-term) AP5779a
    BIN2 Antibody (N-term) (Cat. #AP5779a) western blot analysis in HL-60,CEM,MDA-MB435,A549 cell line lysates (15ug/lane).This demonstrates the BIN2 antibody detected the BIN2 protein (arrow).
  • IHC-P - BIN2 Antibody  (N-term) AP5779a
    BIN2 Antibody (N-term) (Cat. #AP5779a) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BIN2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - BIN2 Antibody  (N-term) AP5779a
    BIN2 Antibody (N-term) (Cat. #AP5779a) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBW5
Other Accession NP_057377.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61874 Da
Antigen Region 14-42 aa
Additional Information
Gene ID 51411
Other Names Bridging integrator 2, Breast cancer-associated protein 1, BIN2, BRAP1
Target/Specificity This BIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human BIN2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBIN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BIN2
Synonyms BRAP1
Function Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Cellular Location Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cell cortex. Cell projection, phagocytic cup Note=Associates with membranes enriched in phosphoinositides Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure
Tissue Location Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Research Areas
Citations (0)

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Scherer, S.E., et al. Nature 440(7082):346-351(2006)
Ge, K., et al. Genomics 67(2):210-220(2000)

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Cat# AP5779a
(40 western blots)
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