|Application ||WB, IHC-P, FC, E|
|Other Accession||P97557, Q8BZN2, Q9GKU7, Q0P583, NP_055194.1|
|Predicted||Bovine, Monkey, Rat|
|Calculated MW||56304 Da|
|Antigen Region||137-166 aa|
|Other Names||Potassium voltage-gated channel subfamily V member 1, Neuronal potassium channel alpha subunit HNKA, Voltage-gated potassium channel subunit Kv81, KCNV1|
|Target/Specificity||This KCNV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the N-terminal region of human KCNV1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNV1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2|
|Tissue Location||Detected in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types.
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Ebihara, M., et al. Gene 325, 89-96 (2004) :
Sano, A., et al. Epilepsia 43 SUPPL 9, 26-31 (2002) :
Salinas, M., et al. J. Biol. Chem. 272(13):8774-8780(1997)
Hugnot, J.P., et al. EMBO J. 15(13):3322-3331(1996)
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