|Application ||WB, IHC-P, E|
|Other Accession||NP_001001502.1, NP_003076.1|
|Calculated MW||14288 Da|
|Antigen Region||93-122 aa|
|Other Names||Beta-synuclein, SNCB|
|Target/Specificity||This SNCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 amino acids from the C-terminal region of human SNCB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNCB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.|
|Tissue Location||Expressed predominantly in brain; concentrated in presynaptic nerve terminals|
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