|Application ||WB, IHC-P, FC, E|
|Other Accession||P48550, P48542, NP_002231.1|
|Calculated MW||48451 Da|
|Antigen Region||26-55 aa|
|Other Names||G protein-activated inward rectifier potassium channel 2, GIRK-2, BIR1, Inward rectifier K(+) channel Kir32, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6, KCNJ6, GIRK2, KATP2, KCNJ7|
|Target/Specificity||This KCNJ6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human KCNJ6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GIRK2, KATP2, KCNJ7|
|Function||This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas|
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