|Application ||WB, IHC-P, E|
|Other Accession||NP_997010.1, NP_997011.1, NP_690875.1|
|Calculated MW||70290 Da|
|Antigen Region||467-496 aa|
|Other Names||Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, Polyamine oxidase, PAOX, PAO|
|Target/Specificity||This PAOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-496 amino acids from the Central region of human PAOX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAOX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.|
|Cellular Location||Peroxisome. Cytoplasm|
|Tissue Location||Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues|
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