|Application ||WB, IHC-P, FC, E|
|Calculated MW||41708 Da|
|Antigen Region||255-283 aa|
|Other Names||SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SAM domain, SH3 domain and nuclear localization signals protein 1, SH3-SAM adaptor protein, SAMSN1, HACS1|
|Target/Specificity||This SAMSN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human SAMSN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAMSN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cell projection, ruffle Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).|
|Tissue Location||Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood|
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