- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
SIAH2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP5878c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5878c-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
SIAH2 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | O43255 |
| Other Accession | Q9I8X5, Q8R4T2, Q06986, Q7SYL3, NP_005058.3 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Xenopus, Zebrafish |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 34615 Da |
SIAH2 Antibody (Center) - Additional info | |
| Gene ID 6478 | |
| Other Names SIAH2; E3 ubiquitin-protein ligase SIAH2; Seven in absentia homolog 2 | |
| Target/Specificity This SIAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human SIAH2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SIAH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SIAH2 Antibody (Center) - Protein Information | |
| Name SIAH2 | |
| Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA | |
| Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear | |
| Tissue Location Widely expressed at low level. | |
SIAH2 Antibody (Center) - Related products
SIAH2 Antibody (Center) - Application data
-
SIAH2 Antibody (Center) (Cat. #AP5878c) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SIAH2 antibody detected the SIAH2 protein (arrow).
-
SIAH2 Antibody (Center) (Cat. #AP5878c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SIAH2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
-
SIAH2 Antibody (Center) (Cat. #AP5878c) flow cytometric analysis of T47D cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
SIAH2 Antibody (Center) - Research Areas
AntibodiesBiological ProcessCell DeathSignal TransductionPost-translational Protein ModificationProtein Modification ProcessBiopolymer ModificationMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessIntracellular Signaling CascadeMulticellular Organismal DevelopmentDevelopmental ProcessCellular Macromolecule Metabolic ProcessCatabolic ProcessCellular Catabolic ProcessDeathProgrammed Cell DeathApoptosisCell CycleBiological RegulationSmall GTPase Mediated Signal TransductionRegulation Of Biological ProcessProteolysisMacromolecule Catabolic ProcessMulticellular Organismal ProcessCellular Macromolecule Catabolic ProcessProtein Modification By Small Protein Conjugation Or RemovalProtein Catabolic ProcessRegulation Of Cellular ProcessUbiquitin-dependent Protein Catabolic ProcessCellular Protein Catabolic ProcessPathway KEGGCell CycleApoptosis
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
