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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > SMPD4 Antibody (N-term)
SMPD4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NXE4 |
| Other Accession | NP_060221.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 97810 Da |
| Antigen Region | 80-108 aa |
| Gene ID | 55627 |
|---|---|
| Other Names | Sphingomyelin phosphodiesterase 4, Neutral sphingomyelinase 3, nSMase-3, nSMase3, Neutral sphingomyelinase III, SMPD4, KIAA1418 |
| Target/Specificity | This SMPD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the N-terminal region of human SMPD4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SMPD4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMPD4 (HGNC:32949) |
|---|---|
| Synonyms | KIAA1418, SKNY |
| Function | Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q6ZPR5} |
| Tissue Location | Widely expressed, with highest levels in heart and skeletal muscle. [Isoform 2]: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level) |
Research Areas
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$ 365.00
$ 140.00
Cat# AP5904a
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