|Application ||WB, E|
|Other Accession||A2ADY9, NP_115717.3|
|Calculated MW||44523 Da|
|Antigen Region||167-196 aa|
|Other Names||Protein DDI1 homolog 2, DDI2|
|Target/Specificity||This DDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the Central region of human DDI2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDI2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193).|
|Cellular Location||Cytoplasm, cytosol|
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