hCG_1745121 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | A4D126 |
Other Accession | NP_001094896.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49873 Da |
Antigen Region | 400-429 aa |
Gene ID | 729920 |
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Other Names | Isoprenoid synthase domain-containing protein, 277-, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, ISPD |
Target/Specificity | This hCG_1745121 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the C-terminal region of human hCG_1745121. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | hCG_1745121 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CRPPA (HGNC:37276) |
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Function | Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:27130732, PubMed:27601598, PubMed:26687144, PubMed:22522421, PubMed:26923585). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5- phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144). |
Cellular Location | Cytoplasm, cytosol. |
Tissue Location | Ubiquitously expressed, with high expression in brain. |
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