|Application ||WB, E|
|Other Accession||Q3B7U9, O35465, NP_036313.3|
|Calculated MW||44562 Da|
|Antigen Region||199-226 aa|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, FKBP8, FKBP38|
|Target/Specificity||This FKBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the Central region of human FKBP8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBP8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.|
|Cellular Location||Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed. Highest levels seen in the brain. Highly abundant in the retina|
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