|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||27774 Da|
|Antigen Region||222-248 aa|
|Other Names||14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1|
|Target/Specificity||This SFN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-248 amino acids from the C-terminal region of human SFN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Present mainly in tissues enriched in stratified squamous keratinizing epithelium|
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