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ABCB4 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP6112a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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- Backgrounds
ABCB4 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P21439 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 141523 Da |
ABCB4 Antibody (Center) - Additional info | |
| Gene ID 5244 | |
| Other Names ABCB4; MDR3; PGY3; Multidrug resistance protein 3; ATP-binding cassette sub-family B member 4; P-glycoprotein 3 | |
| Target/Specificity This ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632~661 amino acids from the central region of human ABCB4. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCB4 Antibody (Center) - Protein Information | |
| Name ABCB4 | |
| Synonyms MDR3, PGY3 | |
| Function Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte | |
| Cellular Location Cell membrane; Multi-pass membrane protein. | |
ABCB4 Antibody (Center) - Related products
AP6112a: ABCB4 Antibody (Center)
ABCB4 Antibody (Center) - Application data
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ABCB4-S639 (Cat. #AP6112a) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ABCB4 antibody detected ABCB4 protein (arrow).
ABCB4 Antibody (Center) - Research Areas
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BACKGROUND
The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
REFERENCES
Eloranta, M.L., et al., Eur J Obstet Gynecol Reprod Biol 105(2):132-135 (2002). Eloranta, M.L., et al., Eur J Obstet Gynecol Reprod Biol 104(2):109-112 (2002). Jacquemin, E., Semin. Liver Dis. 21(4):551-562 (2001). Smit, J.J., et al., Biochim. Biophys. Acta 1261(1):44-56 (1995). Ruetz, S., et al., Cell 77(7):1071-1081 (1994).
