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ABCB6 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6113a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB6 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q9NP58 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 93886 Da |
ABCB6 Antibody (C-term) - Additional info | |
| Gene ID 10058 | |
| Other Names ABCB6; MTABC3; PRP; UMAT; ATP-binding cassette sub-family B member 6, mitochondrial; Mitochondrial ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter | |
| Target/Specificity This ABCB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 813~842 amino acids from the C-terminal region of human ABCB6. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCB6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCB6 Antibody (C-term) - Protein Information | |
| Name ABCB6 | |
| Synonyms MTABC3, PRP, UMAT | |
| Function Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis | |
| Cellular Location Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus | |
| Tissue Location Widely expressed. High expression is detected in the retinal epithelium | |
ABCB6 Antibody (C-term) - Related products
AP6113a: ABCB6 Antibody (C-term)
ABCB6 Antibody (C-term) - Application data
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The anti-ABCB6 C-term Pab (Cat. #AP6113a) is used in Western blot to detect ABCB6 in HL60 cell lysate.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
ABCB6 Antibody (C-term) - Research Areas
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BACKGROUND
The membrane-associated protein ABCB6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
REFERENCES
Mitsuhashi, N., et al., J. Biol. Chem. 275(23):17536-17540 (2000). Furuya, K.N., et al., Cancer Res. 57(17):3708-3716 (1997). Allikmets, R., et al., Hum. Mol. Genet. 5(10):1649-1655 (1996).
