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ABCB7 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP6114a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCB7 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | O75027 |
| Other Accession | Q704E8, Q61102, NP_004290 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 82641 Da |
ABCB7 Antibody (C-term) - Additional info | |
| Gene ID 22 | |
| Other Names ABCB7; ABC7; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7 | |
| Target/Specificity This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723~752 amino acids from the C-terminal region of human ABCB7. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCB7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCB7 Antibody (C-term) - Protein Information | |
| Name ABCB7 | |
| Synonyms ABC7 | |
| Function Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins | |
| Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein (Potential) | |
ABCB7 Antibody (C-term) - Related products
AP6114a: ABCB7 Antibody (C-term)
ABCB7 Antibody (C-term) - Application data
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The anti-ABCB7 C-term Pab (Cat. #AP6114a) is used in Western blot to detect ABCB7 in Jurkat cell lysate.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
ABCB7 Antibody (C-term) - Research Areas
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BACKGROUND
The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
REFERENCES
Allikmets, R., et al., Hum. Mol. Genet. 8(5):743-749 (1999). Csere, P., et al., FEBS Lett. 441(2):266-270 (1998). Mao, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95(14):8175-8180 (1998). Shimada, Y., et al., J. Hum. Genet. 43(2):115-122 (1998). Savary, S., et al., Genomics 41(2):275-278 (1997).
