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ABCB9 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6115a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ABCB9 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q9NP78 |
| Other Accession | NP_062571 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 84475 Da |
ABCB9 Antibody (C-term) - Additional info | |
| Gene ID 23457 | |
| Other Names ABCB9; KIAA1520; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; TAP-like protein | |
| Target/Specificity This ABCB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737~766 amino acids from the C-terminal region of human ABCB9. | |
| Dilution WB~~1:50~200WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCB9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCB9 Antibody (C-term) - Protein Information | |
| Name ABCB9 | |
| Synonyms KIAA1520 | |
| Function ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored | |
| Cellular Location Lysosome membrane; Multi-pass membrane protein. Note=May be located in membrane rafts | |
| Tissue Location Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages | |
ABCB9 Antibody (C-term) - Related products
AP6115a: ABCB9 Antibody (C-term)
RI10019: ABCB9 predesign siRNA
DC04504: Human ABCB9 cDNA Clone
LY12006a: ABCB9 Over-expression Lysate
ABCB9 Antibody (C-term) - Application data
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Western blot analysis of anti-ABCB9 Antibody (C-term) (Cat.#AP6115a) in T47D cell line lysates (35ug/lane). ABCB9(arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
ABCB9 Antibody (C-term) - Research Areas
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BACKGROUND
The membrane-associated protein ABCB9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in three known products which are likely to have different substrate specifications.
REFERENCES
Kobayashi, A., et al., Biochem. Biophys. Res. Commun. 309(4):815-822 (2003). Zhang, F., et al., J. Biol. Chem. 275(30):23287-23294 (2000). Allikmets, R., et al., Hum. Mol. Genet. 5(10):1649-1655 (1996).
