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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDX2 Antibody (N-term)   

CDX2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CDX2 Antibody (N-term) AP6131A
    Western blot analysis of CDX2(arrow) using rabbit polyclonal CDX2 Antibody (N-term)(Cat. #AP6131a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDX2 gene (Lane 2) (Origene Technologies).
  • WB - CDX2 Antibody (N-term) AP6131A
    The anti-CDX2 N-term Pab (Cat. #AP6131a) is used in Western blot to detect CDX2 in placenta tissue lysate.
  • IHC-P - CDX2 Antibody (N-term) AP6131A
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99626
Other Accession P43241
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33520 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 1045
Other Names Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3
Target/Specificity This CDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDX2
Synonyms CDX3
Function Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87%) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4%) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.


Phillips, R.W., et al., Am. J. Surg. Pathol. 27(11):1442-1447 (2003).
Bai, Y.Q., et al., Oncogene 22(39):7942-7949 (2003).
Yamamoto, H., et al., Biochem. Biophys. Res. Commun. 300(4):813-818 (2003).
Eda, A., et al., J. Gastroenterol. 37(2):94-100 (2002).
Moucadel, V., et al., Biochem. Biophys. Res. Commun. 297(3):607-615 (2002).

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$ 295.00
$ 99.00
Cat# AP6131A
(40 western blots)
Availability: In Stock
Bulk Size
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