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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   ICOS Antibody (C-term)   

ICOS Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - ICOS Antibody (C-term) AP6146a
    Formalin-fixed and paraffin-embedded human lymph with ICOS Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - ICOS Antibody (C-term) AP6146a
    ICOS-S171 (Cat. #AP6146a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ICOS antibody detected the ICOS protein (arrow).
  • FC - ICOS Antibody (C-term) AP6146a
    ICOS Antibody (C-term) (Cat. #AP6146a) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6W8
Other Accession NP_036224
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22625 Da
Antigen Region 156-185 aa
Additional Information
Gene ID 29851
Other Names Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Target/Specificity This ICOS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human ICOS.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsICOS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AILIM
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Research Areas
Citations (0)

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ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.


Okamoto, N., et al., Biochem. Biophys. Res. Commun. 310(3):691-702 (2003).
Okamoto, T., et al., J. Rheumatol. 30(6):1157-1163 (2003).
Riley, J.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(18):11790-11795 (2002).
Haimila, K.E., et al., Immunogenetics 53(12):1028-1032 (2002).
Witsch, E.J., et al., Eur. J. Immunol. 32(9):2680-2686 (2002).

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$ 295.00
$ 99.00
Cat# AP6146a
(40 western blots)
Availability: In Stock
Bulk Size
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