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Jagged 2 (JAG2) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y219 |
| Other Accession | NP_002217 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133367 Da |
| Antigen Region | 1209-1238 aa |
| Gene ID | 3714 |
|---|---|
| Other Names | Protein jagged-2, Jagged2, hJ2, JAG2 |
| Target/Specificity | This Jagged 2 (JAG2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1209-1238 amino acids from the C-terminal region of human Jagged 2 (JAG2). |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Jagged 2 (JAG2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JAG2 |
|---|---|
| Function | Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney |
Provided below are standard protocols that you may find useful for product applications.
Background
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. JAG2 is one of several ligands that activate Notch and related receptors.
References
Hayashi, T., et al., J. Androl. 22(6):999-1011 (2001).
Lindner, V., et al., Am. J. Pathol. 159(3):875-883 (2001).
Cereseto, A., et al., J. Cell. Physiol. 185(3):425-431 (2000).
Tsai, S., et al., Blood 96(3):950-957 (2000).
Deng, Y., et al., Genomics 63(1):133-138 (2000).
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