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LAF4 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51826 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133503 Da |
| Antigen Region | 1197-1227 aa |
| Gene ID | 3899 |
|---|---|
| Other Names | AF4/FMR2 family member 3, Lymphoid nuclear protein related to AF4, Protein LAF-4, AFF3, LAF4 |
| Target/Specificity | This LAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1197-1227 amino acids from the C-terminal region of human LAF4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LAF4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFF3 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:6473} |
|---|---|
| Function | Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA. |
| Cellular Location | Nucleus. |
| Tissue Location | Preferentially expressed in lymphoid tissues, highest levels being found in the thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphoid nuclear protein related to AF4 (LAF4) is related to MLLT2 which is also referred to as AF4. LAF4 is a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of LAF4 has defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis.
References
Hiwatari, M., et al., Oncogene 22(18):2851-2855 (2003).
von Bergh, A.R., et al., Genes Chromosomes Cancer 35(1):92-96 (2002).
Liao, X., et al., Mamm. Genome 7(6):467-468 (1996).
Ma, C., et al., Blood 87(2):734-745 (1996).
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