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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Leptin Receptor (LEPR) Antibody (N-term)   

Leptin Receptor (LEPR) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Leptin Receptor (LEPR) Antibody (N-term) AP6151a
    Leptin Receptor (LEPR) Antibody (N-term)(Cat. #AP6151a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LEPR antibody detected the LEPR protein (arrow).
  • FC - Leptin Receptor (LEPR) Antibody (N-term) AP6151a
    Leptin Receptor (LEPR) Antibody (N-term) (Cat. #AP6151a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IHC-P - Leptin Receptor (LEPR) Antibody (N-term) AP6151a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48357
Other Accession NP_002294
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 132494 Da
Antigen Region 23-52 aa
Additional Information
Gene ID 3953
Other Names Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR
Target/Specificity This Leptin Receptor (LEPR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human Leptin Receptor (LEPR).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLeptin Receptor (LEPR) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DB, OBR
Function Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus
Research Areas
Citations (0)

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Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.


Schroth, M., et al., J. Clin. Endocrinol. Metab. 88(11):5497-5501 (2003).
Couturier, C., et al., J. Biol. Chem. 278(29):26604-26611 (2003).
Gavrila, A., et al., J. Clin. Endocrinol. Metab. 88(6):2838-2843 (2003).
Yannakoulia, M., et al., J. Clin. Endocrinol. Metab. 88(4):1730-1736 (2003).
Kado, N., et al., Hum. Reprod. 18(4):715-720 (2003).

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$ 295.00
$ 99.00
Cat# AP6151a
(40 western blots)
Availability: In Stock
Bulk Size
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